Neonatal alloimmune thrombocytopenia associated with maternal-fetal incompatibility for blood group B
نویسندگان
چکیده
منابع مشابه
Fetal and neonatal alloimmune thrombocytopenia.
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is one of the major causes of both severe thrombocytopenia and intracranial haemorrhage in fetuses and term neonates. The incidence of FNAIT is estimated to be one in 1000-2000 births. FNAIT is caused by maternal immunoglobulin G alloantibodies, which cross the placenta and are directed against human platelet antigens (HPA) on fetal platele...
متن کاملFetal and neonatal alloimmune thrombocytopenia.
UNLABELLED Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is the commonest cause of severe neonatal thrombocytopenia. FNAIT is usually suspected in neonates with bleeding or severe, unexplained, and/or isolated postnatal thrombocytopenia. Affected fetuses should be managed in referral centers with experience in the ante-natal management of FNAIT. Close collaboration is required between ...
متن کاملIVIG-Associated Maternal Pancytopenia during Treatment for Neonatal Alloimmune Thrombocytopenia
Background Treatment for neonatal alloimmune thrombocytopenia (NAIT) primarily involves maternal administration of intravenous immunoglobulin (IVIG) therapy and prednisone according to protocols based on risk stratification. While IVIG is generally well tolerated, hematologic side effects are a potential complication. Case We present the successful management of a rare complication of materna...
متن کاملFetal and neonatal alloimmune thrombocytopenia: prenatal interventions.
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a potentially devastating condition, which may lead to intracranial haemorrhage (ICH) in the fetus or neonate, often with death or major neurological damage as consequence. In the absence of screening, preventive measures are only possible in the next pregnancy of women with an affected child. Controversy exists on the best intervention ...
متن کاملNeonatal alloimmune thrombocytopenia complicated by maternal autoimmune thrombocytopenia.
Neonatal alloimmune thrombocytopenia should be suspected in any thrombocytopenic infant born to a healthy non-thrombocytopenic mother. Nevertheless, the condition occurs in only 1 or 2/10 000 births.' More often transient neonatal immune thrombocytopenia results from maternal idiopathic thrombocytopenic purpura. We report the coexistence of alloimmunisation and autoimmunisation against platelet...
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ژورنال
عنوان ژورنال: Transfusion
سال: 2007
ISSN: 0041-1132,1537-2995
DOI: 10.1111/j.1537-2995.2007.01531.x